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You can read the abstract of this article at Serotonin plays a significant role in the brain, particularly in relation to sleep

The terminology is contested, but the underlying observation is not: the metabolic deterioration of neurons, their diminishing capacity to produce and manage energy, appears to be an early and potentially modifiable feature of the disease process, not merely a downstream consequence of it

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This immunomodulatory activity helps to dampen the exaggerated immune response characteristic of UC, thereby reducing mucosal inflammation and mitigating disease activity

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